Epigenetic mechanisms in diabetic vascular complications
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of diabetic vascular complications
Diabetic complications are the major causes of morbidity and mortality in patients with diabetes. Microvascular complications include retinopathy, nephropathy and neuropathy, which are leading causes of blindness, end-stage renal disease and various painful neuropathies; whereas macrovascular complications involve atherosclerosis related diseases, such as coronary artery disease, peripheral vas...
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It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic required, but also for its major complications, affecting both small and large blood vessels. These complications occur in the majority of individuals with both type 1 and type 2 diabetes. Among the most prevalent microvascular complications are kidney disease, blindness, and amputations, with curren...
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The cardiovascular complications associated with diabetes and the closely related metabolic syndrome are of increasing clinical importance throughout the world and especially in the Western hemisphere.1 Although insulin resistance and hyperglycemia are thought to play a pathogenic role during the progression of atherosclerosis, the precise mechanisms involved are not completely clear.2 One fact...
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In the same way that Watson and Crick’s breakthrough in identifying the molecular structure of the DNA double helix revolutionized the last sixty years of molecular biology, the field of epigenetics is set to do the same for the next sixty (or more) years! An alphabet of four letters, and strict guidelines dictating their arrangement, comprise the genome of all known living organisms. This same...
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Epigenetic modifications regulate critical functions that underlie chromosome metabolism. Understanding the molecular changes to chromatin structure and the functional relationship with altered signaling pathways is now considered to represent an important conceptual challenge to explain diabetes and the phenomenon of metabolic or hyperglycemic memory. Although it remains unknown as to the spec...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2011
ISSN: 0008-6363
DOI: 10.1093/cvr/cvr024